Diem Brown lost her battle with cancer.
The 32-year-old MTV reality star has passed way, People magazine confirmed Friday.
Brown first appeared on the network's "Real World/Road Rules Challenge: Fresh Meat" in 2006 and went on to compete in six more challenges.
Brown first revealed she was battling ovarian cancer during her debut season and after rounds of chemotherapy she went into remission that year.
She suffered a relapse in 2012 and this past summer Brown was tragically diagnosed with colon cancer.
"MTV is tremendously sad to hear the news that Diem Brown has lost her long battle with cancer," the network said in a statement.
"We send our deepest condolences to her family and friends. Diem was a true fighter and brought passion to everything she touched. We will miss her."
"I NEED PRAyErs and advice my doctors are seemingly giving up but I won't & can't rollover," Brown tweeted Tuesday. "Whatever option I have to LIVE I'm grabbing!"
"I want people to know that the fight is worth it," she recently told People.
"And that's something that's so important for me."
Brown shared an Instagram photo two months ago from the first day she started treatment again.
"Thanks girls for holding my hand - no matter how many times you go through cancer.. The firs chemo back always gives me so much anxiety & emotions... Love y'all now it's #ChemoTime #KillTheCancer," she captioned the pic.
During her long fight, Brown founded the charity MedGift, which is a gift registry for medical patients.
"MedGift is here to help support you through your journey ... Financially, Physically and Emotionally with our free online support tools," the website reads.